Missoula, MT for Thanksgiving

I would suggest giving more information in regards to your plans, expectations, etc. for the trip? I don't know Missoula well or really at all, but generally speaking people from the south don't realize how cold it gets there and how short their summer is. You never really know, but it could have a foot of snow and be well below freezing the entire week. It could be pretty nice weather. Generally speaking there's not much tourism in Wyoming and Montana during November due to it being between fall and snow season.

Given that, as long as you don't expect to go hiking every daily in shorts and you are flexible with weather and enjoying a different part of the country there's always plenty to do out that way for a week.

ETA; look into and understand that a lot of "tourist" based stuff shuts down in Montana and Wyoming in November until the snow comes. A lot of stuff will close in October and sometimes early October through early December. When I say close, I mean close. Like no hours and not answering the phone. Like I said just look into everything. I'm not trying to recommend not going at all, I'm just trying to help understand what happens.

There's much more to do in Bozeman

Brasserie Port Rouge is a great restaurant, with a New Orleans chef who knows what he is doing. I liked Notorious P.I.G. for a bbq lunch. Ate there twice. Lots of breweries. My favorite was Imagine Nation.