I’ll chime in here since I like you all listened to this podcast and was intrigued.

I had been told a while back by a doctor that I had one of the methylation mutations. She told me to get a methyl b12 supplement and sent me on my way and I kind of forgot about it and didn’t always take it.

After listening to the podcast I remembered this and went down the rabbit hole (ex Chris masterJohn) and am currently waiting on results for a more comprehensive panel as some of the symptoms of these other mutations resonated with things I have experienced.

I decided to supplement as if I have mutations and added methyl b12, P5P (active b6) TMG, SAMe, DIM, etc to my supplement stack. My latest labs came back incredible- I (29M) have always hovered in the 500 range for T and came back with 846 for example. Most other labs came back great. My energy was through the roof, and so on.

Eventually it became too much and I was overpowering my system with the supplements- I discovered niacinamide (b3) can mop up the excess methyl groups and help bring you back down to earth so to speak and that helped a lot.

Overall my thoughts and advice are that if you do have one or more of the mutations, the supplements can change your life for the better. For the record I bought all the supplements separate as I have never found multivitamins to be affective.

However, the methylation system is delicate and can get out of balance if you aren’t careful and can cause extremely uncomfortable issues (look up under and over methylation symptoms). Methylation also affects how your body processes histamine (look up histadelia and Histapenia) just as a warning to those who start to supplement.

I think the testing is worth the cost to check and see if you have these issues, and I would do that first and then supplement after based on what your results are. I would also recommend working with a healthcare practitioner that understands these issues so that they can guide you and can better recognize how the supplements may be affecting you if experience symptoms that are not positive, instead of just experimenting like I did and getting things a little out of balance.

Good luck!