Does anyone have a recommendation for favorite restaurant in downtown Houston?

Biggio’s in the Marriott

You need to narrow it down a bit. Houston has everything. Type of cuisine? Fancy or Casual? Budget?

Hugo’s.
Upscale Mexican.
Get the duck with mole’ poblano sauce.

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Hearsay Gastro Pub - I'm sure I'll get bashed for this

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Wife and I have had several good experiences there. Atmosphere, service, and cocktails are all good. Food isn't exceptional, but still good.

B&B Butcher

Order Chef Tommy’s bacon, it will change your life

/thread

Perry's Steakhouse & Grille

The Mobile area has what I consider bad Mexican food. So my travels to Houston on business 5-6 times a year are greatly anticipated on my end. I really like The Original Ninfa’s on Navigation Street. I absolutely love their fajitas, grilled quail and seafood dishes. The Mexican restaurant right next door, El Tiempo Cantina, is equally good, but has a few other interesting offerings I like. Gosh I can smell the mesquite smoke in the parking lot just thinking about those two places. I also love Hugo’s for Mexican food. Their menu has an entirely different type of Mexican offerings, more upscale dining, and very tasty to put it mildly. Apparently I’m in the mood for Mexican this morning because Houston is one of my favorite big cities due to the variety of delicious restaurants they have. I’d hit those three up since you are going to be there for an extended amount of time. I can 100% guarantee others will chime in with my favorites on steak, BBQ, Asian, and all the other wonderful restaurants in that great city. The residents that have lived in that area for a significant amount of time know a ton of places I've yet to try because I don’t know about them. I’d have a tough time keeping the weight off if I lived over there.

Ended up making a reservation at Vic and Anthony's. Thanks everyone for the recommendations. Will have to try one of the upscale Mexican joints next time

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Dude is asking for a downtown upscale type (wants to take the wife somewhere "nice") place. That's almost as specific a request as one can get for a place as huge as Houston. Certainly more specific than most of the requests one sees here. It's weird the things people will choose to bust people's balls over.

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Calm down Karen. There are upscale restaurants for all cuisine types in Houston.

There is a Brennan’s and Brenner’s here.

There are much better meals in town than both at those price points.