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Started By
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re: Weight loss drug (Semaglutide) cut major adverse cardiovascular events by 20 percent
Posted on 8/9/23 at 7:37 am to UtahCajun
Posted on 8/9/23 at 7:37 am to UtahCajun
quote:
Judging by the dramatic increase in obesity rates in the past 30 years, it must be highly contagious. I wonder what we need to do to stop the spread of such a disease.
I feel like the answer is right in front of our faces
0
Posted on 8/9/23 at 7:39 am to SlowFlowPro
quote:
I am cynical about it, too. Just seems like such a shock to the system there has to be major side effects
quote:
The negative side effects will come out in a few years
Nothing that works this well comes without a price
the major side effects are real and honestly for many, they have to stay on. if you arent obese...shouldnt take it and im big on it.
i just dont think its worth going on a drug for essentially life for 15-20 lbs. lose that shite yourself
now when i say major side effects...there are not many, the drug just mimics natural processes but the minor side effects are very real and why i say you shouldnt take it if its less than say 50-75lbs to lose and honestly should be 75 plus imo.
the feeling of having to shite every 2 seconds, the nausea for many is a big thing. as in can be somewhat life changing
i say all that but i do think its an amazing drug, a true game changer. but if you are going to get on it, please for the love of fricking god, use it as a jump start to learn to eat correctly, learn to lift and learn to monitor your activity levels. use it as a jump start to living a healthy life so you can eventurally get off.
its still an amazing drug and the study in the OP proves that. but its not perfect.
Posted on 8/9/23 at 7:41 am to Will Cover
quote:
I agree. If losing a lot of weight helps the person become more motivated to change their lifestyle and habits to help keep it off after they stop taking the injection, I don't see why anyone should be against it.
A lot of people don’t change lifestyle habits. They just eat less of the same shite foods and still don’t exercise
Posted on 8/9/23 at 7:48 am to Proximo
quote:
There is a reduction in lean body mass shown in the studies
there are not any studies where they have looked at equated protein, we dont know what is causing the lean body mass and if its SMM or not
quote:
The skinny fat drug that may or may not cause cancer and frick your gut motility to hell
there is absolutely no evidence of a risk of cancer. same shite is said about every new drug break through.
Posted on 8/9/23 at 8:42 am to BawtHouse
quote:
Do you also believe the Earth is flat? No? Why not? That is just as factually accurate as the disease of obesity being caused by “laziness” or a lack of will power. Not to say there aren’t exceptions, but the overwhelming majority is due to hormone imbalances. It’s known to be genetic. It’s correctable…with medicine or surgery.
So I’m essentially a flat earther for calling people fat useless and lazy? Genetics my arse. Our ancestors were never this fat before in human history. If you eat healthy and avoid processed food as well as exercise, you’ll be healthy.
Genetics play a role in how muscular you can get sure. This nonsense of genetically fat is insane. Find me a time before 2023 when obesity was this rampant? All these pills create further issues. I’m all for modern medicine, but pills for fat fricks to lose weight is asinine.
Posted on 8/9/23 at 8:58 am to tigerskin
Did the weight loss cause the decrease in cardiovascular events or the drug itself?
I would think the weight loss is driving this.
I would think the weight loss is driving this.
Posted on 8/9/23 at 9:01 am to Proximo
quote:
There is a reduction in lean body mass shown in the studies
Is this not a reasonable expectation? Someone who weighs 280 lbs needs a larger amount of lean mass to support carrying that much weight compared to someone who weighs 170.
This post was edited on 8/9/23 at 9:05 am
Posted on 8/9/23 at 9:03 am to r0cky1
quote:
Find me a time before 2023 when obesity was this rampant?
2022
Posted on 8/9/23 at 9:04 am to slackster
quote:
Why are these hormonal imbalances so prevalent in the US?
Antidepressants
Posted on 8/9/23 at 9:06 am to Basura Blanco
quote:
In 1990, 11.6% of American adults were obese. Today, its over 31%. There is no way in hell it rose that much that fast without some serious changes to the physical make up of the foods we eat. In effect, "easier" (processed)food thru chemistry has contributed to this epidemic as much as anything. And now, as sad as it seems, more chemistry might be the easiest answer to reversing the trend.
The advances in tech since 1990 have allowed us to live much more sedentary lifestyles. This is as much of a factor as anything.
Posted on 8/9/23 at 9:10 am to deathvalleytiger10
quote:
Did the weight loss cause the decrease in cardiovascular events or the drug itself?
I would think the weight loss is driving this.
prolly 10-15% from the weight loss itself based on previous studies that looked at the different diets and determined about 90% of the health benefits comes from the fat loss itself
the rest is prolly from glp-1 control of insulin.
Posted on 8/9/23 at 9:23 am to VADawg
quote:
The advances in tech since 1990 have allowed us to live much more sedentary lifestyles. This is as much of a factor as anything.
Hydrogenated oils and high fructose corn syrup were in wide use in the 1990s. Ubiquitous numbers of handheld devices that can entertain you by yourself for hours were not.
I think the greater contributing food factor is the addition of fructose and/or sugar into everything. It was one thing to drink a Coke or Kool-aid and expect it to be filled with sugar, but when your bread, sandwich meat, and everything else has added sugars, all those excess carbs you get from everything go straight into making fat.
Posted on 8/9/23 at 9:31 am to tigerskin
I bet women are snorting down this pill
This post was edited on 8/9/23 at 9:31 am
Posted on 8/9/23 at 9:32 am to Eli Goldfinger
quote:
I almost died from an adverse reaction to semaglutide.
Big Mac Attack?
Posted on 8/9/23 at 9:38 am to genuineLSUtiger
quote:
It’s the American way. Don’t work on yourself just pop a pill.
I know a few people on it.
It isn't like it forces fat to fall off.
It forces most people to not be able to eat.
That teaching of portion control might actually stick long term.
I can't portion control worth a shite, so i just try to eat cleaner
Posted on 8/9/23 at 9:41 am to SlowFlowPro
quote:
I am cynical about it, too. Just seems like such a shock to the system there has to be major side effects
Semaglutide has been around for about 20 years now, it’s just been more exclusively used for diabetics until recently when it was approved for obesity.
The fiancé is on Oxempic as a diabetic and it’s significantly reduced his need for his injectable insulin throughout the day. He has foot to floor syndrome and it’s helped lessen that morning spike as well. And it’s definitely an appetite suppressant. He used to have food rumination throughout the day and would snack a lot. That’s gone.
He’s had some diarrhea from it but not as bad as when he was on Metformin. And some nausea but it’s common for him to have morning nausea because of what he takes pill wise. He says the side effects aren’t as bad as other diabetic meds he’s been on (and a lot of those have that diarrhea/constipation/nausea component).
This post was edited on 8/9/23 at 9:46 am
Posted on 8/9/23 at 9:41 am to X123F45
quote:
That teaching of portion control might actually stick long term. I can't portion control worth a shite, so i just try to eat cleaner
It’s not teaching them portion control. If a person is on stimulants or sick they can’t eat as much. When they get off the stimulants or get better they’ll go right back to eating the same way. Now maybe it’ll be an eye opener but to actually change habits, they’ll need much more than a pill.
Posted on 8/9/23 at 9:44 am to tigerskin
I dont have a position on this, but I will say that a huge number of 40 year old women in this town are using it and losing weight like crazy. Most of them look so damn weak it is hard to think it is a good thing, but most were not really heavy to begin with.
Posted on 8/9/23 at 9:47 am to BawtHouse
quote:The first step to accepting bullshite as fact is to ignore your own personal experiences and instead accept as fact the words of so-called "experts" with conflicts of interest.
“I did it, so you can do it too” is old school thinking that is dangerous to progress.
"Who You Gonna Believe, Me or Your Lying Eyes?"
quote:quote:Great question! My argument(just an educated guess) would be the amount and availability of calorie dense and processed foods and our cultural habits around food. I would never argue we don’t have an issue with our food in the US. Healthy diet and exercise are absolutely recommended.
Why are these hormonal imbalances so prevalent in the US?
In this thread you've said it's a hormonal imbalance and it's genetic, but when asked about why these hormonal imbalances exist now and not in our grandparents' time, you circle back to the food?
If we simply ate the healthier food our grandparents ate in the amounts our grandparents ate, would our "genetics" not revert back to the hormonal expression they did for our grandparents?
In other words: just stop eating so much garbage?
And I say this as an ex-fatty fast food addict who knows the challenge of changing food habits and losing lots of weight.
Posted on 8/9/23 at 9:51 am to Slidellproud
quote:
It’s not teaching them portion control. If a person is on stimulants or sick they can’t eat as much. When they get off the stimulants or get better they’ll go right back to eating the same way.
Except it will allow their stomach time to shrink, reduce inflammation. In the morbidly obese males it will reduce estrogen, likely increase test.
The biological changes will also help.
The drug isn't for me, but it's silly to deny all of the other residual effects
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