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re: 4 year long study on Wegovy/semaglutide shows heart benefits and safety

Posted on 5/15/24 at 7:18 am to
Posted by Prominentwon
LSU, McNeese St. Fan
Member since Jan 2005
93783 posts
Posted on 5/15/24 at 7:18 am to
quote:

Bawthouse


You seem to know alot about this and have read into it a bit….so you probably know more than I do….

I have a question


quote:

driven by a deficiency of GLP-1, a naturally occurring hormone in our bodies. GLP-1 agonists trigger the increase of production of this hormone to make it rise to more normal levels.


You mentioned processed foods in your first post. Is there a direct correlation between processed food and the lack of GLP-1? Or is it just genetic?
Posted by St Augustine
The Pauper of the Surf
Member since Mar 2006
64442 posts
Posted on 5/15/24 at 7:19 am to
quote:

The hate stems from societal stigma around obesity and psychological conditioning to believe obesity is strictly an issue of lacking will power. This has fueled a culture of fat shaming(which actually has made it harder to fight the disease large scale). It’s due to internalization and feeling a certain way about themselves and inadequacies. Then they lash out a spit venom. Very standard projection. The GLP-1s are accomplishing something that all the fad diets, “move more eat less” campaigns, and societal fat shaming couldn’t accomplish. Broad scale success in fighting the disease of obesity. Let me put it another way. It is providing more years of life to those that take it. It is improving the quality of life of those that take it. It lowers other risk factors like the linked article discussed. It hurts nobody, which is amazing considering how triggered so many people get over this. What is even more amazing is that it appears to help break many addiction chains due to how the reward center in the brain responds. Gambling. Alcoholism. Smoking. Nail biting. And so on. You would think this is something everyone could get behind, but sadly no. Our society is still largely driven by antiquated thinking.



Yeah I don’t get the vitriol. I am not taking these meds nor will I likely ever have to. If it’s helping someone get a jumpstart on being healthy I’m not going to sit here on my throne of adequate daily activity and diet and throw stones. The inherent need to be right and better than on the internet is a fricking plague.
Posted by Tiger_n_Texas
Member since Aug 2014
1018 posts
Posted on 5/15/24 at 7:22 am to
quote:

All the better if you do, but I know probably a dozen who have done nothing but take the shot, be conscientious of their intake (stop eating when they begin feeling full), and have lost a lot of weight. I’d say 20% weight reduction (40-50#).


The problem with this method is the massive muscle loss percentage and the rate of weight-loss. It falls off too fast and leaves the person with loose skin and weak.
Posted by PGAOLDBawNeVaBroke
Member since Dec 2023
817 posts
Posted on 5/15/24 at 7:26 am to
Enjoy shitting your bed and destroying your large intestine. Big pharma is on your side….yep
Posted by Prominentwon
LSU, McNeese St. Fan
Member since Jan 2005
93783 posts
Posted on 5/15/24 at 7:27 am to
quote:

And yet you see everyone with cancer around you and you just don’t know why…can’t be the diabetes drug tho huh….


Wtf are you talking about ?
Posted by BawtHouse
Member since Dec 2021
220 posts
Posted on 5/15/24 at 7:27 am to
quote:

But it’s obvious that is not what is afflicting most people.


Incorrect. The hormonal imbalance is the root cause driver behind the majority of cases of people with the disease of obesity. Fix the root cause, and the symptoms of the disease subside.

Now, there are compounding issues further down the line. The availability of calorie dense foods has become more and more a driver, but it isn’t the root cause. If patients don’t have the food noise and satiation is achieved with less food intake and faster, the availability of calorie dense foods wouldn’t cause symptoms of the disease of obesity. The regulatory process in the body is the root cause.

I’ll avoid the rabbit holes and keep on point. However, for the record, there are plenty of compounding issues. One of them is our food supply and the lack of financial access to healthy whole foods
Posted by Prominentwon
LSU, McNeese St. Fan
Member since Jan 2005
93783 posts
Posted on 5/15/24 at 7:27 am to
quote:

Enjoy shitting your bed and destroying your large intestine.


Ok, destroying large intestines. Can you provide more info on that?
Posted by lsu777
Lake Charles
Member since Jan 2004
31575 posts
Posted on 5/15/24 at 7:34 am to
quote:

BawtHouse


bro.... :bow:...you should stick around more, you saved me tons of post this morning by owning these dumbasses.

Posted by dtett
Jiggacity
Member since Oct 2018
520 posts
Posted on 5/15/24 at 7:35 am to
Nah. He relies on feelings to come to his conclusions.
Posted by PGAOLDBawNeVaBroke
Member since Dec 2023
817 posts
Posted on 5/15/24 at 7:38 am to
One of many….

Gastrointestinal issues
Posted by Rust Cohle
Baton rouge
Member since Mar 2014
1971 posts
Posted on 5/15/24 at 7:40 am to
quote:

Obese people losing weight improves their cardiovascular health -- doesn't that go without saying?


Not just obese, but most weights, normal and overweight also. What was failed to mention in the OP post was the most important finding in this trial, and was that they found Cardiovascular benefit without weight loss.
Posted by Mo Jeaux
Member since Aug 2008
59157 posts
Posted on 5/15/24 at 7:43 am to
What’s causing the hormonal imbalance? Seems like that’s your root cause. Again, the obesity epidemic is a relatively recent occurrence.
This post was edited on 5/15/24 at 7:46 am
Posted by Epic Cajun
Lafayette, LA
Member since Feb 2013
32807 posts
Posted on 5/15/24 at 7:43 am to
quote:

Incorrect. The hormonal imbalance is the root cause driver behind the majority of cases of people with the disease of obesity.

Oh, it’s not the fact that they shovel 5k calories into their gullet everyday?
Posted by Prominentwon
LSU, McNeese St. Fan
Member since Jan 2005
93783 posts
Posted on 5/15/24 at 7:44 am to



So constipation as a side effect = “destroying large intestines”?

So NyQuil also has constipation side effects. Are we going to use the same verbiage for NyQuil that you use for these drugs?
Posted by LSUGrrrl
Frisco, TX
Member since Jul 2007
33393 posts
Posted on 5/15/24 at 7:46 am to
quote:

I’m sure the side effect will be cancer after about 10 years of use.


Y’all realize that these drugs have been used in some form or another for longer than some posters here have been alive, right? And yet, none of these “predictions” have been noted in patients who used them.
Posted by lsu777
Lake Charles
Member since Jan 2004
31575 posts
Posted on 5/15/24 at 7:46 am to
quote:

You mentioned processed foods in your first post. Is there a direct correlation between processed food and the lack of GLP-1? Or is it just genetic?


ok so this is going to be kind of long and complicated

1) calories & protein are what matter, just remember that

2) we know the enzyme soluble DPP-4(sDPP-4) immediately suppresses the bodies ability to produce GLP-1 and GIP(the two peptides in mounjaro & zepbound). DPP-4 is just another peptide aka amino acid chain. It is one of the longest at 727 aminos. Something like HGH is only 121 aminos, so it a really long chain. There are others being studied like DPP-6

3) as far as i know, we do not know every food or mechanism in which sDPP-4 is released but there is a ton of studies going on to try and figure it out. What we do know is

sDPP-4 activity is increased with increased insulin levels and is released into the adipose tissue. So in general, highly palatable processed foods are going to spike insulin and make the body release more sDPP-4 causing one to no feel satisfied because GLP-1&GIP are suppressed.


here are some good resources on it if you really want to understand the actions at a cellular level

LINK

LINK
Posted by Semper Gumby
Member since Dec 2021
306 posts
Posted on 5/15/24 at 7:47 am to
quote:

It is providing more years of life to those that take it.


Not so fast buddy. These magic drugs haven’t been around long enough to prove this or the opposite.
Posted by lsu777
Lake Charles
Member since Jan 2004
31575 posts
Posted on 5/15/24 at 7:47 am to
quote:

Oh, it’s not the fact that they shovel 5k calories into their gullet everyday?


which is usually caused by high DPP-4 activity which suppresses GLP1 & GIP levels in the body.
Posted by Lsupimp
Ersatz Amerika-97.6% phony & fake
Member since Nov 2003
79042 posts
Posted on 5/15/24 at 7:48 am to
quote:

It’s the result of poor self control, laziness, lack of pride, gluttony, and a myriad of of other negative traits.


Nothing in the thread demonstrates the challenge that obese people have or the judgement they face more than this one. Obesity ALWAYS and UNIQUELY among the medical issues has to be framed as a MORAL failing. Even when the science is there about hormonal deficiencies that shows that a high percentage of people never feel satiated due to a specific hormonal deficiency that can now be addressed, people still want to shame the obese with moralistic lectures.

We now have a medication that quells the noise ( that’s what is happening folks) caused by a specific hormone they are lacking and allowing these people to eat normally, exercise more, look better, have more confidence, engage the world with more vigor and optimism, stop taking their other medications, avoid that heart stent, avoid dying 15 years early because they have diabetes and they are still being told they should face the “ contempt” of others.

The resistance to these medications on “ moral grounds” lol are silly. We should be talking about legitimate side effects and leave the moralizing to internet grifters and Muslim clerics.

FTR, taking this medication has been a life saver for me and my hereditary esophageal issues that were ruining my quality of life. Having to puke every time I take a bite of solid food is a real drag . Being satiated on a protein shake and being able to function at a high level on half the calories is just the blessing my GI tract needed and keeps me out of the emergency room and GI office. The more ya know…


Posted by LSUGrrrl
Frisco, TX
Member since Jul 2007
33393 posts
Posted on 5/15/24 at 7:48 am to
quote:

Not so fast buddy. These magic drugs haven’t been around long enough to prove this or the opposite.


That’s literally not true
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