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2
Posted on 5/15/24 at 7:53 am to Semper Gumby
quote:
These magic drugs haven’t been around long enough to prove this or the opposite.
The studies have been going since the 70s.
This post was edited on 5/15/24 at 8:15 am
Posted on 5/15/24 at 7:54 am to Semper Gumby
quote:
Not so fast buddy. These magic drugs haven’t been around long enough to prove this or the opposite.
wtf you talking about, been around for 2 decades
and all you stupid fricks that want to post like this
you understand that GLP-1 and GIP are naturally occurring hormones in the body right? all these medicines are....are just peptides. they help up the levels in the body to normal levels
thats like saying testosterone replacement or growth hormone replacement are goign to kill people. or that the ghrh/ghrp peptides are going to kill people
yall also understand that insulin is a peptide...right
just so we are clear...these started being studies in the late 70's and early 80s. has been out since 2005 for treatment of diabetes.
but yet now that they got approval for weightloss too....its suddenly going to start killing people?
and why do yall cite side effects that are found in about 0.01% of people that take the medicine?
and GLP-1 is anticatabolic you stupid fricks. it doesnt cause muscle loss, the extreme low calories and lack of protein that some ingest while on it causes that. Guess what, dumb people do stupid shite, but they still look better then they did when fat.
and i would be willing to bet 99% of the people on this board assigning moralistic views to the medicine and putting down those that take it.....are obese. We know that most of the OT is fat AF from the BMI threads.
bunch of fat guys, telling other fat guys....do lose weight that away...its cheating!!!
cheating who? its not a competition.
Posted on 5/15/24 at 7:54 am to Epic Cajun
quote:
Oh, it’s not the fact that they shovel 5k calories into their gullet everyday?
Sure calories in vs calories out, but you’re minimizing the scenario. It’s like asking “why did the car get in a wreck?” and determining that it’s because they hit each other.
Even people knowledgeable in calories, and food weight approximation can’t guess there calorie intake correctly without a scale and chart, and are likely off 300-400 calories for the day. That could result in an excess of 120,000 cal a year, or over a 30 pound weight gain. Point being something has changed, as previous generations did not need to count calories.
Posted on 5/15/24 at 7:56 am to Tiger_n_Texas
quote:
The problem with this method is the massive muscle loss percentage and the rate of weight-loss. It falls off too fast and leaves the person with loose skin and weak.
It almost has to be taken in combination with a heavy protein diet, calcium and with medical weigh ins and blood work that monitors muscle loss and hormonal changes. The data shows people have a lot of muscle loss especially at the beginning and then we they are more able to exercise having lost weight, they gain muscle back.
Also remember that muscle loss applies in almost all diets save high protein/low carb specific diets. Which imho, is what these meds should be paired with. A weekly injection, lots of healthy proteins and exercise.
Posted on 5/15/24 at 7:57 am to Ingeniero
I have never seen a forum on the internet as obsessed with fast food and fast food prices as this one so its no shock the lazy obese fatties try and reject anything related to health and fitness 
Posted on 5/15/24 at 8:00 am to Lsupimp
quote:
I’m sure the side effect will be cancer after about 10 years of
quote:
Again, there are studies, there are personal stories , dozens of medical journal articles, health and medical expert interviews and podcasts, etc. Take the time to learn the most basic stats and facts and concepts before chiming in with “!you gonna get AIDS, bruh “.
I think a lot of people railing on these drugs don't understand they've been used for a long while already with diabetics.
*ETA: I am not on these drugs, so I have no dog in the fight.
Posted on 5/15/24 at 8:01 am to Prominentwon
quote:
You mentioned processed foods in your first post. Is there a direct correlation between processed food and the lack of GLP-1? Or is it just genetic?
There is absolutely a genetic component, but I’m not willing to commit that there aren’t other drivers suppressing the adequate production of GLP-1 as well. There are lots of ongoing studies around this. Your question is another nature vs nurture scenario. My belief is that it is a combination of both.
We should all aspire to do better with our lives and be supportive of others doing the same. Treating medical conditions medically AS WELL as promoting healthy lifestyle should ALWAYS be the goal.
Posted on 5/15/24 at 8:03 am to ronricks
Multiple threads per week about Cane’s, where the caniac combo has 124g of carbs, 104 g of fat and almost 2000 calories, but so many of are fat because of a hormonal imbalance. I’m not as against these drugs as you are, but the one thing that does bother me about them is that they don’t address the actual root cause, which is our SAM. We can’t upset BigFood, so BigPharma comes in to save the day.
Posted on 5/15/24 at 8:04 am to Rust Cohle
quote:
Shockingly 90% of people who lose weight gain it back.
The human body is weird. If a person has become obese, the body will fight losing weight and try to induce that person to maintain that obese size.
The psychology and biology of hunger and food pleasure is really crazy. It's the hardest addiction to deal with because of the body's hard-wiring. There is only one biological influence stronger in humans than caloric desire and that's water desire. We're talking about literal evolutionary and biological hard-wiring at the most basic (and strongest) level.
That's one of the crazy things about these drugs is that they actually, allegedly, start to unwind this pathological hardwiring. If this is possible, this is the best path to increase the odds of that person not relapsing.
Posted on 5/15/24 at 8:05 am to Prominentwon
quote:
So with that information and if I’m reading that correctly, yes, process foods are made to be addictive and suppresses GLP-1.
yes
so we know that in the end once calories and protein are equated we lose body fat at around the same rate no matter the diet strategy aka keto, carnivore, Intermittent fasting, iso caloric, low fat etc
we also know that protein is almost impossible to store as body fat and carbs are harder to store than dietary fat.
we also know from multi year studies that those that stick to a ketogenic style diet tend to unconsciously lower caloric intake...but what is different is that is the only style diet that dosnt cause a subsequent lowering of caloric output in the form of non exercise activity thermogensis aka NEAT.
we also know large secretions of insulin causes the release of sDPP-4 especially when those secretions are within close time frames. closer and more releases the higher the sDPP-4 activity in the adipose tissue. and we know sDPP-4 suppresses both GLP-1 and GIP
so they are looking at the possibilities that diets like the keto/carnivore and even carb cycling diets work in slowly lowering calories without knowing, is because the suppression of sDPP-4 which is allowing the body to slowly normalize GLP-1 & GIP which is causing those eating this style to normalize caloric intake at a much lower level than those on other style diets.
Posted on 5/15/24 at 8:05 am to Solo Cam
quote:
will be sadly disappointed when they find out what it does to bone density and soft tissue.
Why do you frickers completely make shite up?
Posted on 5/15/24 at 8:06 am to Prominentwon
quote:
So with that information and if I’m reading that correctly, yes, process foods are made to be addictive and suppresses GLP-1.
That's what it sounds like to me. My question, then, would be are these deficiencies passed on to the next generation, or are they remedied by avoiding processed garbage that suppress the necessary hormones?
Posted on 5/15/24 at 8:06 am to PrimeTime Money
quote:
Americans never used to be this fat. Humans throughout history never used to be fat like this, apart from a relatively small number.
Affluent society issues.
Our brains are not static or uniform and are very malleable. In addition to the impact of affluence and availability, our brains get re-wired to bad food. The bad food is literally engineered to do this, and it accomplishes the goal very quickly.
Posted on 5/15/24 at 8:07 am to Mo Jeaux
quote:
What’s causing the hormonal imbalance? Seems like that’s your root cause. Again, the obesity epidemic is a relatively recent occurrence.
Valid question. We evolve from nature and nurture. Genetically we change over time and our environment changes us over time. I would argue the increase is due to both. It’s been increasing for a very long time, though. It’s not a new pattern
Posted on 5/15/24 at 8:07 am to SlowFlowPro
quote:
That's one of the crazy things about these drugs is that they actually, allegedly, start to unwind this pathological hardwiring. If this is possible, this is the best path to increase the odds of that person not relapsing.
it normalizes the hormonal suppression that usually occurs when obese. talking suppression of GLP-1 and GIP through releases of sDPP-4
Posted on 5/15/24 at 8:07 am to BawtHouse
quote:
You would think this is something everyone could get behind, but sadly no. Our society is still largely driven by antiquated thinking.
People have emotional reactions to fat people that I would guess are rooted in evolution. Fat people might be perceived to be selfish and lazy and therefore a threat to the tribe.
I appreciate your overall sentiment but at 50yo I’ve lived long enough to have learned that there is no magic pill. There will be a massive side effect to these drugs. And if history is any guide it will likely come just after the drug companies have recouped their investment plus a few billion more and the subsequent lawsuits will be a few billion less than the profits.
Posted on 5/15/24 at 8:08 am to Mo Jeaux
quote:
What’s causing the hormonal imbalance? Seems like that’s your root cause. Again, the obesity epidemic is a relatively recent occurrence.
Clearly the toxic modern diet. It’s a poison. It makes food a reaction to cravings instead of an appetite satiation. When I moved to Japan I was strong and fit, after 3 months there I was positively svelte. Natural foods beget healthy hormones and vice versa. The crappier one eats the more out of whack all the hormones that drive satiation are. Anybody who threw out the processed carbs and sees how comparatively efficient their bodies become, understands that. And that’s how I view the medications, they allow obese people a reset of their body process. People that take these meds, suddenly the food cravings having stopped, begin to really think on an intentional level about their bodies and food and health.
Posted on 5/15/24 at 8:13 am to Lsupimp
quote:
FTR, taking this medication has been a life saver for me and my hereditary esophageal issues that were ruining my quality of life. Having to puke every time I take a bite of solid food is a real drag . Being satiated on a protein shake and being able to function at a high level on half the calories is just the blessing my GI tract needed and keeps me out of the emergency room and GI office. The more ya know…
You know, if you just lifted weights and walked half a mile and not be such a lazy fatty, your esophagus wouldn’t be an issue, amirite?
Posted on 5/15/24 at 8:14 am to ronricks
quote:
I have never seen a forum on the internet as obsessed with fast food and fast food prices as this one so its no shock the lazy obese fatties try and reject anything related to health and fitness
while you and i agree that the medicine should accompany resistance training, certain step counts and an actual dietary strategy other than eating less because the medicine makes you full, we will never agree that the medicine should not be used
1) we know in the obese that GLP-1 and GIP are suppressed to much lower levels
2) we know most other hormones like Test are lowered and Cortisol/Estrogen are higher
this medicine fixes the GLP-1/GIP issues which inturn allows them to eat less and have less cravings which allows for easier fat loss which allows the T:E ratio to fix itself in many cases and allows the body to stop pumping out cortisol
one other thing people are not talking about it, the medicines help the heart, no matter if it is accompanied with weight loss or not
and also the medicine's future role in treating addiction. we know it helps with alcohol addiction and sex addiction but it is also being studied to help with all addictions
it also led us to discover the sDPP-4 and how it works and sDPP-4 and ghrelin antogist like mk677 and there role in helping people eat and gain weight as maybe a solution to eating disorders on the other end of the spectrum.
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